Def Leppard will perform the pre-game show at Wembley as the stadium prepares to host the first NFL International series game between the Oakland Raiders and the Miami Dolphins.
It is the ninth fixture to be played in London since 2007.
Miami touched down in Britain only on Friday, but the Raiders have been here since Monday aiming to get familiar with their new surroundings as they try to kick-start their season after three defeats on the bounce.
Meanwhile, Def Leppard's lead singer, Joe Elliott, said: "I know what the atmosphere in the ground is like for 'our' football so I'm really looking forward to performing there before the NFL game and of course soaking up the excitement of the actual match. I can't wait."
A limited number of tickets are still sale but the stadium said they were selling fast.
Oakland Raiders vs Miami Dolphins is live from Wembley Stadium and will be televised on Sky Sports 2 HD from 5.30pm.
