IT IS a dilemma that no parent should ever have to face – deciding whether to risk your child being brain damaged by allowing her to have chemoradiotherapy for an aggressive brain tumour.
Yet this is exactly the conundrum Sean and Debra faced over their daughter Iris Connolly.
Three years ago on a family holiday in Malaysia, the married couple, from West Horndon, were told that the three-year-old had a tumour the size of a ping pong ball in her brain.
After successful operations, both abroad and at home, the family had to decide whether to agree to radiotherapy and chemotherapy treatment for their child.
"You're completely desperate," recalled her mum Debra Teo.
"You'll do anything, you'd pay anything, you'd say anything and you want to believe that there's some magical cure."
Earlier this year, Brighton mum Sally Roberts lost her High Court case to go against doctors' wishes and use alternative medicine rather than radiotherapy to treat her seven-year-old son Neon.
The Connollys' own decision to go through with this treatment was difficult and they say the lack of information given to parents by doctors can make it even tougher.
"We encountered some of the same problems as Sally in getting in-depth information from doctors, so I think her campaign to get more information available to parents is a reasonable one," said Debra. "She does have a point and we're living with the after-affects of radiotherapy on a very young brain."
After poring over scientific research papers during their own research, it became clear to them the treatment could make the difference to Iris's survival.
Iris, now 6, then endured six weeks of radiotherapy and 48 weeks of chemotherapy and although it was successful, her parents admitted they will remain worried about her health for the rest of their lives.
"She has a lifetime increased risk of having other unrelated tumours, said Debra.
"For example, if she smokes she'd be much more likely to get lung cancer.
"We have to be completely paranoid for the rest of her life about sun block and her exposure to the sun."
Iris is also likely to suffer from memory loss and her parents are aware she may have to start writing with the help of a keyboard because she may never be able to process letters as quickly.
The family remains cautious but believe luck has been on their side since Iris was diagnosed.
Debra said: "The first bit of chemo ran with the radio.
"It varies from child to child but if she'd been a few months younger they wouldn't have done the radiotherapy first because they won't do it for a child under the age of three."
At the start of her treatment Iris was very weak.
She struggled to keep food down and was paralysed down the right side of her body, leaving her unable to walk.
Her worried mum took to sleeping beside her every night for a year, as Sean recalled: "It was the only way she could get any sleep."
The family, completed by three year old daughter Athina, found ways to cope through communication, routine and the support of others.
"We came up with the rule that mummy and daddy would be in charge at home and Iris would be in charge at hospital so that she felt empowered there," Sean said.
With a wry smile Debra added: "She had one or two tantrums at home and she'd just say, 'I want to go back to hospital, I want to be in charge'.
"Fair enough really."
Since their ordeal others have turned to the family to ask for advice on how to cope with the challenges that face young families dealing with cancer.
Their advice is simple.
"Ask for help a bit sooner than we did," said Debra.
"We weren't aware of all the resources and organisations out there.
"First you have to get over the fear that your child may die, you've got to believe that it's possible they may live and then you have to get your head around what life's going to be like for them.
"At some stage you have to take a bigger view about what is going to happen after treatment.
"What's going to happen in five, 10, 20 years."
Among those who provided that support to the family were the Little Havens Hospice, social workers and the Rainbow Trust.
Determined to "give something back," the Connollys set about raising £35,000 to support a care worker at the Trust.
Iris did a tricycle ride, Debra shaved her head and Sean grew an elaborate twirled moustache.
Last year, Debra successfully completed the London Marathon.
Her proud husband said: "I think it was the promise she had made that got her over the finish line."
Iris has regained much of her strength since completing her radiotherapy.
She has grown much of her strength and appetite back since the end of her treatment and started at nearby West Horndon Primary School last year.
This Easter, Debra enjoyed watching her develop after giving up her veterinary practice to devote more time to her children.
For Iris, the presence of her little sister is a real motivation and they learned to walk together.
Debra added: "The progress she's made has been amazing and we're very much focusing on the positives."
TIMELINE OF IRIS'S PROGRESSFebruary 2010: Iris is diagnosed with a brain tumour during a family holiday in Malaysia. She undergoes 13 hours of surgery to remove 40 per cent of the tumour
March 2010: The entire tumour is removed after surgery at London's Great Ormond Street Hospital
April 2010: Started six weeks of daily radiotherapy at University College London Hospital
May 2010: Debra's head shave
July 2010: Started full chemotherapy which lasted 48 weeks in the end
August 2010: Managed to walk again
September 2010: Returned to preschool
June 2010: Completed chemotherapy treatment
October 2011: Visit from New Zealand by big half-brother Samuel
December 2011: Went to visit family in New Zealand
January 2012: Started full-time reception